Activation of PARP-1 in neurons may act as a switch to a cell-death program as demonstrated in the presence of DNA-damaging agents. The DNA damage signaling pathway is activated in neurodegenerative disorders and leads to the activation of the DNA repair enzyme poly ADP-ribose polymerase-1 (PARP-1). Oxidative stress induces DNA damage and induces cell cycle arrest, which in turn activates apoptosis.
Recently, several studies have linked oxidative stress to the etiology of neurodegenerative diseases and discovered a link between apoptosis and neurodegeneration. The pathogenesis of neurodegenerative disorders is not well understood and neither is the mechanism of apoptosis following brain injuries. In addition, neurodegenerative disorders are a leading cause of death among the elderly, making the development of a treatment for these devastating diseases a crucial problem. More than 150,000,000 people worldwide are affected by neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease. Wondershare Filmora is a powerful video editor for creating amazing videos.Ĭreates a video from an existing clip or a set of imagesĭNA damage and repair in neurodegenerative diseases: a potential role for immunotherapy.
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